Lab manager - research analyst Drug discovery

• A one-year contract with the intention of extension.
• Classification in salary scale 8M: € 3,626 to € 5,134 gross for a full-time employment (depending on education and experience). Additionally, you will receive an 8.3% year-end bonus. Calculate your net salary here.
• Vacation hours: 194.4 hours per year for a full-time employment and the possibility to save up hours.
• 100% public transport reimbursement. Do you come by walking, cycling, or by car? Then you will receive a reimbursement of €0.21 per km (for the car, a maximum of 40 km one way applies).
• Do you come by bike? Make use of our good bicycle scheme.
• Pension accrual at ABP, of which we pay 70% of the premium.
• Free and unlimited access to training courses, including GoodHabitz, in our learning environment.
• An active staff association and a Young Amsterdam UMC association, both of which organize fun (sporty) activities and events.

As lab manager/analyst, you are the technical and organizational hub of the group. You ensure the lab runs smoothly and perform experiments yourself.

In this way, you provide reliable, well-documented data. You are also involved in the start and further development of new projects. You work closely with PhD students, postdocs, and partners from protein chemistry, medicinal chemistry, and structural biology. Together, you monitor progress towards project milestones: a biophysical assay for the MCL1/MDM2 interaction (after 8 months), new chemical binders for MCL1 (after 18 months), and MDM2-dependent degraders for MCL1 (after 24 months). Additionally, you are the point of contact for collaboration partners, improve protocols, and assist with reporting to project partners and the funding agency.

Your responsibilities include, among other things:

• coordinating the daily affairs in the lab: task distribution, planning of experiments, and coordination with colleagues;
• managing orders, supplies, suppliers, and the lab budget, and maintaining and calibrating equipment;
• monitoring safety, quality, and compliance with protocols, permits, and registrations (including GMO, chemicals, CCD, and waste streams);
• setting up, performing, and optimizing biochemical assays, such as a DNA-encoded small molecule library screen and pulldown assays, and screening and validating new binders and degraders in cellular glioblastoma models (including western blot, viability assays, flow cytometry, and cell culture of patient-derived cell lines);
• onboarding and supervising new employees and students, and recording and updating protocols and the electronic lab notebook.

You are accurate, organizationally strong, and practically minded. You enjoy working in a multidisciplinary team, maintain an overview, and like to help others get started. This is how you ensure the lab runs smoothly.