Clinical Pharmacy Intern: Optimization of Palliative Sedation

Continuous palliative sedation (CPS) is applied to patients in the terminal phase of life experiencing refractory suffering. Midazolam is the first-choice agent for CPS, but there is currently no generally accepted definition of a successful treatment.

During this internship, you will contribute to research into the pharmacodynamic objective of successful CPS with midazolam. The results of this research will form the basis for future pharmacokinetic/pharmacodynamic (PK/PD) modeling and the development of a model-informed dosing tool for midazolam in CPS.

Within this project, you will participate in setting up, conducting, and analyzing a Delphi study among a multidisciplinary panel of healthcare professionals and other stakeholders, such as relatives of patients with experience in CPS. Through multiple rounds of questionnaires, consensus will be reached on the characteristics that define successful CPS.

Developing and refining Delphi questionnaires.

Coordinating and conducting the Delphi study.

Analyzing Delphi data and assessing consensus outcomes.